Measles Virus Fusion Protein (MV F) (AA 451-550) anticorps (FITC)

N° du produit ABIN729410

L’anticorps Lapin Polyclonal anti- a été validé pour IF (cc) et IF (p). Il convient pour détecter dans des échantillons de Measles Virus et Virus.

Aperçu rapide pour Measles Virus Fusion Protein (MV F) (AA 451-550) anticorps (FITC) (ABIN729410)

Antigène: Measles Virus Fusion Protein (MV F)

Reactivité: Measles Virus, Virus

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: FITC

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit

Épitope: AA 451-550

Réactivité croisée: Virus

Réactivité croisée (Details): Measles virus

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from Measles virus fusion protein

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Measles Virus Fusion Protein (MV F)

Autre désignation: Measles Virus Fusion Protein

Classe de substances: Viral Protein

Sujet:

Synonyms: Fusion glycoprotein F0, Fusion glycoprotein F1, MeV, Morbillivirus

Background: Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).

ID gène: 1489800

UniProt: P69353