MAFA anticorps

N° du produit ABIN729898

Cet anticorps Lapin Polyclonal détecte spécifiquement MAFA dans WB, IF (p) et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour MAFA anticorps (ABIN729898)

Antigène: MAFA (Transcription Factor MafA (MAFA))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAFA est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-MAFA anticorps

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Mafa

Isotype: IgG

Information d'application

Indications d'application: WB: (1:100-1000), IHC-P: (1:100-500), IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur MAFA

Antigène: MAFA (Transcription Factor MafA (MAFA))

Autre désignation: Mafa

Sujet:

Synonyms: Mafa homolog, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A,Pancreatic beta-cell-specic transcriptional activator,avianV-maf musculoaponeurotic fibrosarcoma oncogene homolog A, MAFA_MOUSE.

Background: Insulin gene expression is regulated by several islet-enriched transcription factors. However, MAFA is the only beta cell-specific activator. MAFA selectively induces endogenous insulin transcription in non-beta cells. MAFA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MAFA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.

ID gène: 389692

Pathways: Hormone Transport