CBX5 anticorps (pTyr24)

N° du produit ABIN729943

Cet anticorps Lapin Polyclonal détecte spécifiquement CBX5 dans WB, ELISA, IHC (p), IF (p), IF (cc) et IHC (fro). Il présente une réactivité envers Humain et Drosophila melanogaster et a été mentionné dans 1 publication.

Aperçu rapide pour CBX5 anticorps (pTyr24) (ABIN729943)

Antigène: CBX5 (Chromobox Homolog 5 (CBX5))

Reactivité: Humain, Drosophila melanogaster

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBX5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-CBX5 anticorps

Épitope: pTyr24

Réactivité croisée: Humain

Réactivité croisée (Details): Fruit Fly

Homologie: Drosophila

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from Drosophila Melanogaster HP1 around the phosphorylation site of Tyr24

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-CBX5 (ABIN729943)

Terzuoli, Meini, Cucchi, Catalani, Cialdai, Maggi, Giachetti, Ziche, Donnini: "Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-kB pathway activation." dans: PLoS ONE, Vol. 9, Issue 1, pp. e84358, (2014) (PubMed).

Détails sur CBX5

Antigène: CBX5 (Chromobox Homolog 5 (CBX5))

Autre désignation: HP1

Sujet:

Synonyms: Heterochromatin protein 1, HP1, Non-histone chromosomal protein C1A9 antigen, CG8409

Background: HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. HP1 proteins are relatively small proteins (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are requiredfor binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin.

ID gène: 34119