Chp2 anticorps (CF®488A)

N° du produit ABIN7652374

Cet anticorps Souris Monoclonal détecte spécifiquement Chp2 dans WB et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour Chp2 anticorps (CF®488A) (ABIN7652374)

Antigène: Chp2

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Chp2 est conjugé à/à la CF®488A

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: CPTC-CHP2-1

Détail du produit anti-Chp2 anticorps (CF®488A)

Fonction: Calcineurin B homologous protein 2 / HCC Antigen 520(CPTC-CHP2-1), CF488A conjugate

Attributs du produit: Calcineurin B homologous protein 2, also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na/H exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant human full-length CHP2 protein

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Western blot 1-2 μg/mL, Immunofluorescence: 1-2 μg/mL, Optimal dilution for a specific application should be determined.

Commentaires:

Positive Control: MCF-7, PC-3, HT29, K562 or Jurkat cell lysates. Human appendix or testis.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur Chp2

Antigène: Chp2

Autre désignation: Calcineurin B homologous protein 2

Sujet:

Synonyms: Calcineurin B homologous protein 2, Calcineurin-like EF hand protein 2, HCA520, hepatocellular carcinoma antigen gene 520

Gene Symbol: CHP2

Poids moléculaire: 22 kDa

ID gène: 63928

UniProt: O43745