Desmoglein 3 anticorps (AA 379-491) (CF®740)

N° du produit ABIN7653142

Cet anticorps Souris Monoclonal détecte spécifiquement Desmoglein 3 dans IHC et IHC (fp). Il présente une réactivité envers Humain.

Aperçu rapide pour Desmoglein 3 anticorps (AA 379-491) (CF®740) (ABIN7653142)

Antigène: Desmoglein 3 (DSG3)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Desmoglein 3 est conjugé à/à la CF®740

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: DSG3-2837

Détail du produit anti-Desmoglein 3 anticorps (CF®740)

Épitope: AA 379-491

Fonction: Desmoglein-3 (Squamous Cell Marker)(DSG3/2837), CF740 conjugate

Attributs du produit: Recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80 % ) and specificity (100 %) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant fragment (around aa 379-491) human DSG3 protein

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: A431 cells. Skin or Lung Squamous Cell Carcinoma (SCC).

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % rBSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur Desmoglein 3

Antigène: Desmoglein 3 (DSG3)

Autre désignation: Desmoglein-3

Sujet:

Synonyms: 130 kDa pemphigus vulgaris antigen (PVA), Balding (Bal), Cadherin family member 6 (CDHF6), Desmoglein-3 (DSG3)

Gene Symbol: DSG3

Tissue Expression: Epidermal cells

Poids moléculaire: 130 kDa

ID gène: 1830

UniProt: P32926