DMC1 anticorps (Biotin)

N° du produit ABIN7653215

L’anticorps Souris Monoclonal anti-DMC1 a été validé pour IHC et IHC (fp). Il convient pour détecter DMC1 dans des échantillons de Humain, Souris, Rat et Boeuf (Vache).

Aperçu rapide pour DMC1 anticorps (Biotin) (ABIN7653215)

Antigène: DMC1 (DNA Meiotic Recombinase 1 (DMC1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DMC1 est conjugé à/à la Biotin

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: 2H12-4

Détail du produit anti-DMC1 anticorps (Biotin)

Fonction: DMC1(2H12/4), Biotin conjugate

Attributs du produit: DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the doublestrand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Nibrin and Dmc1. Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients. Dmc1 is specifically involved in meiotic recombination. An alternative spliced form of Dmc1, designated Dmc1-D, is deleted for a region between the two motifs involved in nucleotide binding. The alternatively spliced Dmc1-D transcript is detected in both male and female germ cells, indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant full-length human DMC1 protein.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: HeLa cells. Cervix or prostate.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur DMC1

Antigène: DMC1 (DNA Meiotic Recombinase 1 (DMC1))

Autre désignation: DMC1

Sujet:

Synonyms: Disrupted meiotic cDNA 1 homolog, dJ199H16.1, DMC1 dosage suppressor of mck1 homolog, DMC1H, DNA meiotic recombinase 1, HsLim15, LIM15, Meiotic recombination protein DMC1/LIM15 homolog, MGC150472, MGC150473

Gene Symbol: DMC1

Poids moléculaire: 37 kDa

ID gène: 11144

UniProt: Q14565