LSP1 anticorps (AA 174-278) (CF®647)

N° du produit ABIN7656430

Cet anticorps Souris Monoclonal détecte spécifiquement LSP1 dans IHC et IHC (fp). Il présente une réactivité envers Humain.

Aperçu rapide pour LSP1 anticorps (AA 174-278) (CF®647) (ABIN7656430)

Antigène: LSP1 (Lymphocyte-Specific Protein 1 (LSP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LSP1 est conjugé à/à la CF®647

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: LSP1-3025

Détail du produit anti-LSP1 anticorps (CF®647)

Épitope: AA 174-278

Fonction: Lymphocyte Specific Protein 1 (LSP1) / pp52(LSP1/3025), CF647 conjugate

Attributs du produit: LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15. 5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant fragment of human LSP1 protein (around aa174-278)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: Human tonsil, colon, spleen or Hodgkin lymphoma (IHC-P).

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur LSP1

Antigène: LSP1 (Lymphocyte-Specific Protein 1 (LSP1))

Autre désignation: Lymphocyte Specific Protein 1

Sujet:

Synonyms: WP34, pp52, lymphocyte specific protein 1, leukocyte specific protein 1

Gene Symbol: LSP1

Tissue Expression: Leukocytes

Poids moléculaire: 52 kDa

ID gène: 4046

UniProt: P33241