MMP3 anticorps (AA 317-327) (CF®594)

N° du produit ABIN7656642

Cet anticorps anti-MMP3 est un anticorps Souris Monoclonal détectant MMP3 dans WB, IHC et IHC (fp). Adapté pour Humain.

Aperçu rapide pour MMP3 anticorps (AA 317-327) (CF®594) (ABIN7656642)

Antigène: MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MMP3 est conjugé à/à la CF®594

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: 1B4

Détail du produit anti-MMP3 anticorps (CF®594)

Épitope: AA 317-327

Fonction: MMP3 (Marker of Metastasis and Rheumatoid Arthritis)(1B4), CF594 conjugate

Attributs du produit: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant fragment corresponding to amino acids 317-327 of human MMP3.

Isotype: IgG1, kappa

Information d'application

Indications d'application: ELISA: Use at 2-4 μg/mL for coating, Order without BSA, Optimal dilution for a specific application should be determined.. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody

Commentaires:

Positive Control: A431 cells. Prostate or Lung Carcinoma.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur MMP3

Antigène: MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

Autre désignation: MMP3

Sujet:

Synonyms: CHDS6, Matrix metalloproteinase 3, Matrix metalloproteinase-3, MMP3, Proteoglycanase, SL1, STMY1, STR1, Stromelysin-1, Transin 1

Gene Symbol: MMP3

Poids moléculaire: 57 kDa

ID gène: 4314

UniProt: P08254