Recombinant TIMP2 anticorps (N-Term) (CF®740)

N° du produit ABIN7656994

Cet anticorps Lapin Monoclonal détecte spécifiquement TIMP2 dans IHC et IHC (fp). Il présente une réactivité avec des échantillons de Humain, Rat, Souris, Boeuf (Vache), Lapin, Poisson zèbre (Danio rerio) et Cobaye.

Aperçu rapide pour Recombinant TIMP2 anticorps (N-Term) (CF®740) (ABIN7656994)

Antigène: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Lapin, Poisson zèbre (Danio rerio), Cobaye

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TIMP2 est conjugé à/à la CF®740

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: TIMP2-2488R

Détail du produit anti-TIMP2 anticorps (CF®740)

Épitope: AA 56-66, N-Term

Fonction: TIMP2 (Tissue Inhibitor of Metalloproteinase 2) (TIMP2/2488R), CF740 conjugate

Attributs du produit: This antibody recognizes a protein of 21 kDa, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2). It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: A synthetic peptide from the N-terminus of human TIMP2 protein (aa56-66) (DSGNDIYGNPI)

Isotype: IgG

Information d'application

Indications d'application: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Immunohistology (formalin): 1-2 μg/mL for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined by user

Commentaires:

Positive Control: HeLa cells. Normal Placenta. Breast, Colon, Endometrial, Prostate or Ovarian Carcinoma.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % rBSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur TIMP2

Antigène: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Autre désignation: TIMP2

Sujet:

Synonyms: Metalloproteinase inhibitor 2, TIMP metallopeptidase inhibitor 2, TIMP-2, TIMP2, Tissue Inhibitor of Metalloproteinase 2

Gene Symbol: TIMP2

Poids moléculaire: 21 kDa

ID gène: 7077

UniProt: P16035

Pathways: cAMP Metabolic Process