Recombinant HLA DQ anticorps

N° du produit ABIN7657100

L’anticorps anti-HLA DQ Monoclonal Souris est utilisé pour la détection de HLA DQ dans des échantillons de Humain et Porc. Il a été validé pour IP, WB et Func.

Aperçu rapide pour Recombinant HLA DQ anticorps (ABIN7657100)

Antigène: HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Porc

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HLA DQ est non-conjugé

Application: Immunoprecipitation (IP), Western Blotting (WB), Functional Studies (Func)

Clone: RSPV-L3

Détail du produit anti-HLA DQ anticorps

Fonction: HLA-DQ (MHC II)(rSPV-L3)

Attributs du produit: Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: T4-positive CTL clone HG-38

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: Raji cells. Tonsil or lymph node

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, no BSA, no azide

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Store at -20 °C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur HLA DQ

Antigène: HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))

Autre désignation: HLA-DQ

Sujet:

Synonyms: CELIAC1, DC 4 alpha chain Gluten sensitive enteropathy (celiac disease) (GSE), HLA class II histocompatibility antigen DQ(1) alpha chain, HLA class II histocompatibility antigen DQ(3) alpha chain, IDDM1, Leucocyte antigen DQA1, Major histocompatibility complex class II DQ alpha 1 (HLA DQA1), Major histocompatibility complex class II DQ beta 1 (HLA DQB1), MHC class II antigen HLA DQ beta 1, MHC class II HLA DQ alpha 1, MHC class II HLA DQ beta glycoprotein

Gene Symbol: HLA-DQ

Poids moléculaire: 60 kDa

ID gène: 3117, 3118, 3119

UniProt: P01908, P01909, P01920