Estrogen Receptor alpha anticorps (pTyr537)

N° du produit ABIN732413

L’anticorps Lapin Polyclonal anti-Estrogen Receptor alpha a été validé pour WB, ELISA, FACS, IHC (p), IF (cc), IF (p) et IHC (fro). Il convient pour détecter Estrogen Receptor alpha dans des échantillons de Humain.

Aperçu rapide pour Estrogen Receptor alpha anticorps (pTyr537) (ABIN732413)

Antigène: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Estrogen Receptor alpha est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-Estrogen Receptor alpha anticorps

Épitope: pTyr537

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Cow

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human ER alpha around the phosphorylation site of Tyr537

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Estrogen Receptor alpha

Antigène: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Autre désignation: Estrogen Receptor alpha

Sujet:

Synonyms: ER alpha Tyr537, ER alpha Y537, ER alpha Y537, ER alpha Tyr537, p-ER alpha Tyr537, p-ER alpha Y537, Estrogen Receptor alpha Y537, Estrogen Receptor alpha Tyr537, Estradiol receptor, Estrogen receptor alpha, Estradiol Receptor-alpha, Estrogen Receptor 1, Atherosclerosis, susceptibility to, included, DKFZp686N23123, ER Alpha, ER, ER-alpha, ERalpha, ER[a], Era, ESR, ESR1, ESR1_HUMAN, ESR2, ESRA, Estr, Estrogen receptor 1 alpha, Estrogen resistance, included, HDL cholesterol, augmented response of, to hormone replacement, included, Myocardial infarction, susceptibility to, included, NR3A1, Nuclear receptor subfamily 3 group A member 1, OTTHUMP00000017718, OTTHUMP00000017719, RNESTROR.

Background: Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER Alpha and ER Beta. ER Alpha and ER Beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.

ID gène: 2099

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly