NRF1 anticorps

N° du produit ABIN7658108

L’anticorps Souris Monoclonal anti-NRF1 a été validé pour WB, IHC et IHC (fp). Il convient pour détecter NRF1 dans des échantillons de Humain.

Aperçu rapide pour NRF1 anticorps (ABIN7658108)

Antigène: NRF1 (Nuclear Respiratory Factor 1 (NRF1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NRF1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: NRF1-2609

Détail du produit anti-NRF1 anticorps

Fonction: NRF1(NRF1/2609)

Attributs du produit: The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs). A family of NF-E2 related proteins, which are collectively known as the Cap 'n' collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, JunB and JunD) to activate gene expression, specifically the detoxifying enzyme, NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1. Nrf3 is highly expressed in placenta, B cells and monocytes. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant full-length human NRF1 protein

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: Ubiquitous expression, strongest in skeletal muscle.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS, 0.05 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur NRF1

Antigène: NRF1 (Nuclear Respiratory Factor 1 (NRF1))

Autre désignation: NRF1

Sujet:

Synonyms: alpha pal, Alpha palindromic-binding protein, Alpha-pal, locus control region factor 1, NFE2 related factor 1, Nuclear respiratory factor 1 (NFR-1)

Gene Symbol: NFE2L1

Poids moléculaire: 30 kDa (bZIP region), 65-120 kDa (glycosylated)

ID gène: 4899

UniProt: Q16656

Pathways: Regulation of Lipid Metabolism by PPARalpha