PD-1 anticorps (CF®568)

N° du produit ABIN7658960

L’anticorps Rat Monoclonal anti-PD-1 a été validé pour FACS et Func. Il convient pour détecter PD-1 dans des échantillons de Souris.

Aperçu rapide pour PD-1 anticorps (CF®568) (ABIN7658960)

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp PD-1 est conjugé à/à la CF®568

Application: Flow Cytometry (FACS), Functional Studies (Func)

Clone: RMP1-14

Détail du produit anti-PD-1 anticorps (CF®568)

Fonction: PD1, Mouse(RMP1-14), CF568 conjugate

Attributs du produit: PD-1 is expressed on a subset of CD4-CD8-thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B-lymphocytes and myeloid cells. Additionally, Pdcd1mRNA is expressed in developing B-lymphocytes during the pro-B-cell stage. The RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production co-stimulated by macrophages (but not by dendritic cells and B cells). Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: PDCD1 transfected BHK cells

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: Spleen, Thymus or Lymph Node.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur PD-1

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Autre désignation: PD1

Sujet:

Synonyms: CD279, CD279 antigen, PD1, PDCD1, Programmed cell death 1, Programmed cell death protein 1, Systemic lupus erythematosus susceptibility 2 (SLEB2)

Tissue Expression: B-cells|Myeloid cells|T-cells

Poids moléculaire: ~50-55 kDa

ID gène: 18566

UniProt: Q02242

Pathways: Cancer Immune Checkpoints