Spastin anticorps (CF®740)

N° du produit ABIN7660079

L’anticorps Souris Monoclonal anti-Spastin a été validé pour WB et IF. Il convient pour détecter Spastin dans des échantillons de Souris, Rat et Humain.

Aperçu rapide pour Spastin anticorps (CF®740) (ABIN7660079)

Antigène: Spastin (SPAST)

Reactivité: Souris, Rat, Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Spastin est conjugé à/à la CF®740

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: Sp 3G11-1

Détail du produit anti-Spastin anticorps (CF®740)

Fonction: Spastin(Sp 3G11-1), CF740 conjugate

Attributs du produit: The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility, membrane trafficking, proteolysis, protein folding and organelle biogenesis. Spastin, a member of the AAA protein family, is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm, where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST, SPG4) cause the most common form of spastic paraplegia 4, an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent, retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40 % of all autosomal dominant HSPs. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant full-length human Spastin protein.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: HeLa cells. Rat brain extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % rBSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur Spastin

Antigène: Spastin (SPAST)

Autre désignation: Spastin

Sujet:

Synonyms: ADPSP, FSP2, Spast, Spatin, SPG4

Gene Symbol: SPAST

Poids moléculaire: 52 kDa

ID gène: 6683

Pathways: Dynamique des Microtubules, M Phase, Regulation of Cell Size