SCCA1 anticorps (CF®488A)

N° du produit ABIN7660241

L’anticorps Souris Monoclonal anti-SCCA1 a été validé pour WB. Il convient pour détecter SCCA1 dans des échantillons de Humain.

Aperçu rapide pour SCCA1 anticorps (CF®488A) (ABIN7660241)

Antigène: SCCA1 (Squamous Cell Carcinoma Antigen 1 (SCCA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SCCA1 est conjugé à/à la CF®488A

Application: Western Blotting (WB)

Clone: CPTC-SERPINB3-2

Détail du produit anti-SCCA1 anticorps (CF®488A)

Fonction: Squamous Cell Carcinoma Antigen 1(CPTC-SERPINB3-2), CF488A conjugate

Attributs du produit: Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine proteases, such as neutrophil elastase. Serpins are family of serine protease inhibitors, contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant expression of serpin family members can contribute to a number of conditions, including emphysema (-1 antitrypsin deficiency), fatal bleeding (elastase to Thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). SCCA1 expression has been demonstrated to promote oncogenic transformation and epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and its silencing in breast cancer cells has been shown to halt their proliferation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant human full-length SERPINB3 protein

Isotype: IgG1, kappa

Information d'application

Indications d'application: Western blot 0.5-1.0 μg/mL, Optimal dilution for a specific application should be determined.

Commentaires:

Positive Control: U-2197, HaCaT, Squamous cells. Expressed in some hepatocellular carcinoma.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur SCCA1

Antigène: SCCA1 (Squamous Cell Carcinoma Antigen 1 (SCCA1))

Autre désignation: Squamous Cell Carcinoma Antigen 1

Sujet:

Synonyms: HsT1196, Protein T4 A, Protein T4-A, SCC, SCCA-PD, SCCA1, SCCAPD, Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 3, Serpin B3, SERPINB3, Squamous cell carcinoma antigen 1, T4 A, T4-A

Gene Symbol: SERPINB3

Poids moléculaire: 39 kDa

ID gène: 6317

UniProt: P29508