TIMP1 anticorps (AA 72-82) (CF®405S)

N° du produit ABIN7660833

Cet anticorps anti-TIMP1 est un anticorps Souris Monoclonal détectant TIMP1 dans WB, IHC et IHC (fp). Adapté pour Humain.

Aperçu rapide pour TIMP1 anticorps (AA 72-82) (CF®405S) (ABIN7660833)

Antigène: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TIMP1 est conjugé à/à la CF®405S

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: 2A5

Détail du produit anti-TIMP1 anticorps (CF®405S)

Épitope: AA 72-82

Fonction: TIMP1 (Marker of Lymph Node Metastasis)(2A5), CF405S conjugate

Attributs du produit: TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases -1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 is identical to EPA (erythroid-potentiation activity). PTH has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart tissues. Studies have demonstrated that TIMP1 is useful as a biomarker for early detection of colorectal cancer, outperforming CEA. Additionally, TIMP1 studies have demonstrated its role in CRC tumorigenesis, as well as observing its overexpression in metastatic lymph nodes. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: A synthetic peptide (aa 72-82) of human TIMP1 protein (FQALGDAADIR)

Isotype: IgG1, kappa

Information d'application

Indications d'application: ELISA: Use Ab at 2-4 μg/mL for coating, Order Ab without BSA, Optimal dilution for a specific application should be determined.. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody

Commentaires:

Positive Control: 293 cells. Colon Carcinoma.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur TIMP1

Antigène: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Autre désignation: TIMP1

Sujet:

Synonyms: Collagenase inhibitor, EPO, Erythroid-Potentiating Activity (EPA), Fibroblast collagenase inhibitor, Human Collagenase Inhibitor (HCI), Metalloproteinase inhibitor 1, Tissue Inhibitor of Metalloproteinase 1 (TIMP1)

Gene Symbol: TIMP1

Poids moléculaire: 23 kDa

ID gène: 7076

UniProt: P01033