Recombinant TNFSF15 anticorps

N° du produit ABIN7661141

L’anticorps Souris Monoclonal anti-TNFSF15 a été validé pour IHC et IHC (fp). Il convient pour détecter TNFSF15 dans des échantillons de Humain.

Aperçu rapide pour Recombinant TNFSF15 anticorps (ABIN7661141)

Antigène: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TNFSF15 est non-conjugé

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: RVEGI-1283

Détail du produit anti-TNFSF15 anticorps

Fonction: TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) (rVEGI/1283)

Attributs du produit: VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant full-length human VEGI protein

Isotype: IgG1, kappa

Information d'application

Indications d'application: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Immunohistology (formalin): 1-2 μg/mL for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA pH 9.0 for 10-20 minutes followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined by user

Commentaires:

Positive Control: Endothelial cells. Colon, intestine, placenta, lung, liver, kidney, pancreas, spleen and prostate.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, no BSA, no azide

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Store at -20 °C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur TNFSF15

Antigène: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Autre désignation: TNFS15

Sujet:

Synonyms: TNF ligand-related molecule 1 (TL1A), Tumor necrosis factor (ligand) superfamily member 15 (TNFSF15), Vascular endothelial growth inhibitor 192a, Vascular endothelial growth inhibitor (VEGI), VEGI192A

Gene Symbol: TNFSF15

Tissue Expression: Endothelial cells

Poids moléculaire: 22 kDa

ID gène: 9966

UniProt: O95150

Pathways: Positive Regulation of Endopeptidase Activity, Autophagy