Cortisol Binding Globulin anticorps

N° du produit ABIN7670581

Cet anticorps anti-Cortisol Binding Globulin est un anticorps Lapin Polyclonal détectant Cortisol Binding Globulin dans WB, ELISA et IF. Adapté pour Humain et Souris.

Aperçu rapide pour Cortisol Binding Globulin anticorps (ABIN7670581)

Antigène: Cortisol Binding Globulin

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cortisol Binding Globulin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-Cortisol Binding Globulin anticorps

Fonction: Cortisol Binding Globulin/CBG/SERPINA6 Polyclonal Antibody(Capture/Detector)

Purification: Antigen Affinity Purification

Immunogène: Recombinant Human Cortisol Binding Globulin/CBG/SERPINA6 SERPINA6 Protein expressed by Mammalian

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000,IF 1:50-1:200,ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Date de péremption: 12 months

Détails sur Cortisol Binding Globulin

Antigène: Cortisol Binding Globulin

Sujet: Corticosteroid-binding gLobuLin,CBG,Serpin A6,Transcortin,SERPINA6,CBG,Corticosteroid-binding globulin (CBG),also known as SerpinA6,is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG,and promotes a significant and local release of glucocorticoids (over 90 % of them are bound to CBG in human plasma). In this context,CBG directs glucocorticoids to sites of inflammation,and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration,and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable,human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.

Poids moléculaire:

Calculated MW: 45kDa

ObservedMW: 60kDa

UniProt: P08185