PRTN3 anticorps

N° du produit ABIN7670731

Cet anticorps anti-PRTN3 est un anticorps Lapin Polyclonal détectant PRTN3 dans ELISA. Adapté pour Humain.

Aperçu rapide pour PRTN3 anticorps (ABIN7670731)

Antigène: PRTN3 (Proteinase 3 (PRTN3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRTN3 est non-conjugé

Application: ELISA

Détail du produit anti-PRTN3 anticorps

Fonction: Proteinase 3/PRTN3/PR3 Polyclonal Antibody(Capture/Detector)

Purification: Antigen Affinity Purification

Immunogène: Recombinant Human Proteinase 3/PRTN3/PR3 protein expressed by Mammalian

Isotype: IgG

Information d'application

Indications d'application: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Date de péremption: 12 months

Détails sur PRTN3

Antigène: PRTN3 (Proteinase 3 (PRTN3))

Autre désignation: Proteinase 3/PRTN3

Sujet: AGP,PRTN,proteinase,Leukocyte proteinase,Neutrophil proteinase,ACPA,AGP7,C-ANCA,CANCA,MBN,MBT,NP-4,NP4,P29,PR-3,PR3,PRTN3,proteinase 3,Myeloblastin,C-ANCA antigen,Leukocyte proteinase 3,Neutrophil proteinase 4,Wegener autoantigen,Proteinase 3 (PRTN3), also known as Myeloblastin (MBN), is a 32-33 kDa member of the peptidase S1 family of enzymes. It is expressed by monocytes and neutrophils, the latter of which either secretes it, sequesters it in azurophilic granules, or expresses it on the cell surface. When secreted, it acts on HK and activates the kinin pathway. In azurophilic granules, it aids in the digestion of phagocytosed material. On the cell surface, it likely acts on ECM. Human PRTN3 proprecursor is 231 amino acids (aa) in length. It contains an Ala26Glu27 propeptide that is removed during maturation, a 221 aa mature enzyme (aa 28-248), and an eight aa C?terminal propeptide (aa 249-256). Within the cell, a 35 kDa immature form exists, on the cell surface, both constitutively inactive, and induced active forms may be found, often in a noncovalent association with CD177/NB1. Over aa 26-249, human PRTN3 shares 68 % aa identity with mouse PRTN3.

UniProt: P24158