CXCR3 anticorps

N° du produit ABIN7673000

Cet anticorps Souris Monoclonal détecte spécifiquement CXCR3 dans WB et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour CXCR3 anticorps (ABIN7673000)

Antigène: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CXCR3 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 6F7

Détail du produit anti-CXCR3 anticorps

Fonction: CXCR3-specific antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: peptide(N-terminal,extracellular domain)

Immunogen: chemokine(C-X-C motif) receptor 3

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:500-1:5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur CXCR3

Antigène: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Autre désignation: CXCR3

Sujet:

Synonyms: C-X-C chemokine receptor type 3 (CXC-R3, CXCR-3)|CKR-L2|G protein-coupled receptor 9|Interferon-inducible protein 10 receptor (IP-10 receptor)|CXCR3|GPR9

Background: CXCR3(C-X-C chemokine receptor type 3) is a G protein-coupled, seven-transmembrane domain chemokine receptor that is expressed on the surface of a number of cell types, including activated CD4+ and CD8+ T cells, NK and NK-T cells, plasmacytoid dendritic cells, and some B cells(PMID: 16847335). CXCR3 binds and is activated by the three IFN-gamma-inducible chemokines: CXCL9, CXCL10, and CXCL11. Binding of these ligands to CXCR3 has been implicated in regulating T-cell infiltration during inflammation and tissue injury(PMID: 17250586). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms, CXCR3B, mediates the angiostatic activity of CXCR3 ligands and also acts as functional receptor for CXCL4(PMID:12782716). This monoclonal antibody is specific to CXCR3B.

Poids moléculaire: 40 kDa+43 kDa

ID gène: 2833

UniProt: P49682