GPX4 anticorps (AA 107-197)

N° du produit ABIN7673337

L’anticorps Souris Monoclonal anti-GPX4 a été validé pour WB, IHC, ELISA et IF. Il convient pour détecter GPX4 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour GPX4 anticorps (AA 107-197) (ABIN7673337)

Antigène: GPX4 (Glutathione Peroxidase 4 (GPX4))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GPX4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Clone: 5C8

Détail du produit anti-GPX4 anticorps

Épitope: AA 107-197

Fonction: GPX4 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 107-197aa

Immunogen: glutathione peroxidase 4 (phospholipid hydroperoxidase)

Isotype: IgG2b

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:500-1:2000, IF: 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur GPX4

Antigène: GPX4 (Glutathione Peroxidase 4 (GPX4))

Autre désignation: GPX4

Sujet:

Synonyms: Phospholipid hydroperoxide glutathione peroxidase GPX4 (PHGPx)|Glutathione peroxidase 4 (GPx-4, GSHPx-4)|GPX4

Background: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

Poids moléculaire: 22 kDa

ID gène: 2879

UniProt: P36969