Anthrax Toxin Lethal Factor anticorps (Internal Region)

N° du produit ABIN7794899

Cet anticorps Lapin Polyclonal détecte spécifiquement Anthrax Toxin Lethal Factor dans . Il présente une réactivité envers Bacillus anthracis.

Aperçu rapide pour Anthrax Toxin Lethal Factor anticorps (Internal Region) (ABIN7794899)

Antigène: Anthrax Toxin Lethal Factor (Lef)

Reactivité: Bacillus anthracis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Anthrax Toxin Lethal Factor est non-conjugé

Application: Veuillez nous consulter SVP

Détail du produit anti-Anthrax Toxin Lethal Factor anticorps

Épitope: Internal Region

Fonction: Anti-Anthrax Lethal Factor (Intermediate Domain)

Specificité: Rabbit Anti-Anthrax Lethal Factor (Anthrax LF) recognizes an epitope in the intermediate domain of Anthrax LF. This polyclonal antibody was purified using affinity chromatography. Background Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin protective antigen (PA), lethal factor (LF), and edema factor (EF)1,2. PA binds to two related proteins on the cell surface, these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR)3 and capillary morphogenesis protein 2 (CMG2),4 although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF, the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.

Information d'application

Restrictions: For Research Use only

Stockage

Concentration: 0.5 μg/mL

Buffer: This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02 % sodium azide as a preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Détails sur Anthrax Toxin Lethal Factor

Antigène: Anthrax Toxin Lethal Factor (Lef)

Autre désignation: Anthrax Lethal Factor

Sujet: Anthrax Lethal Factor,