SARS-CoV-2 Nucleocapsid anticorps (Biotin)

N° du produit ABIN7794970

Cet anticorps anti-SARS-CoV-2 Nucleocapsid est un anticorps Souris Monoclonal détectant SARS-CoV-2 Nucleocapsid dans . Adapté pour SARS Coronavirus-2 (SARS-CoV-2).

Aperçu rapide pour SARS-CoV-2 Nucleocapsid anticorps (Biotin) (ABIN7794970)

Antigène: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)

Reactivité: SARS Coronavirus-2 (SARS-CoV-2)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SARS-CoV-2 Nucleocapsid est conjugé à/à la Biotin

Application: Veuillez nous consulter SVP

Clone: NP1-C5

Détail du produit anti-SARS-CoV-2 Nucleocapsid anticorps (Biotin)

Fonction: Anti-SARS-CoV-2 Nucleocapsid (N) (Clone NP1-C5) Biotin

Specificité: Anti-SARS-CoV-2 Nucleocapsid, clone NP1-C5, specifically targets an epitope on the SARS-CoV-2 nucleocapsid protein. Furthermore, it is reported to bind to the RNA binding domain of the N protein. Antigen Distribution The nucleocapsid protein is expressed in the internal nucleocapsid of SARS-CoV-2. Background Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 belongs to the Coronaviridae family, and its single-stranded, positive-sense RNA genome shares 79.6 % identity with SARS-CoV1. The spike (S), envelope (E), membrane (M), and nucleocapsid proteins (N) are four essential structural proteins of SARS-CoV-22. The 46 kDa N protein is highly conserved and shares 90 % homology with SARS-CoV3. Similar to SARS-CoV, SARS-CoV-2 has an N-terminal (NTD) and C-terminal domain (CTD), linked by a linker region. The NTD binds to RNA, while the CTD self-oligomerizes4,5, aiding viral genome packaging into a helical ribonucleoprotein complex6. The N protein also participates in viral transcription, replication, and modulation of cell signaling pathways7,8. Some vaccine and diagnostic assays9 have focused on the N protein as it is highly expressed during infection and activates antibodies3,10 and memory T cells11,12, found in convalescent sera. The N-protein also evades the innate immune system by inhibiting RNAi13, identifying it as a potential therapeutic target.

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Concentration: 0.5 μg/mL

Buffer: This Biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1 % BSA and 0.09 % sodium azide as a preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.

Détails sur SARS-CoV-2 Nucleocapsid

Antigène: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)

Autre désignation: SARS-CoV-2 Nucleocapsid (N)

Classe de substances: Viral Protein

Sujet: COV2-NP1-C5, SARS-CoV-2 Nucleocapsid, SARS-CoV-2 Nucleoprotein, Protein N, SARS-CoV N Protein,