Recombinant ErbB2/Her2 (Trastuzumab Biosimilar) anticorps

N° du produit ABIN7795083

L’anticorps Humanized Monoclonal anti-ErbB2/Her2 (Trastuzumab Biosimilar) a été validé pour FACS et in vivo. Il convient pour détecter ErbB2/Her2 (Trastuzumab Biosimilar) dans des échantillons de Humain.

Aperçu rapide pour Recombinant ErbB2/Her2 (Trastuzumab Biosimilar) anticorps (ABIN7795083)

Antigène: ErbB2/Her2 (Trastuzumab Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Humanized

Clonalité: Monoclonal

Conjugué: Cet anticorp ErbB2/Her2 (Trastuzumab Biosimilar) est non-conjugé

Application: Flow Cytometry (FACS), In vivo Studies (in vivo)

Classe de qualité: Research Grade

Détail du produit anti-ErbB2/Her2 (Trastuzumab Biosimilar) anticorps

Expression System: Mammalian cells

Fonction: Trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant

Attributs du produit: Trastuzumab, a humanized monoclonal antibody, interferes with the HER2/neu receptor and is mainly used to treat certain breast cancers, especially HER2-positive metastatic breast cancer. Combined with chemotherapy, trastuzumab increases both survival and response rate. There are four closely related receptor tyrosine kinases in the ErbB family of receptors: EGFR (ErbB-1, HER1 in humans), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Bound by members of the epidermal growth factor family (EGF-family) of extracellular protein ligands, the HER receptors embedded in the cell membrane promote cell growth and division by turning genes on and off. The HER2 pathway stimulates cell proliferation if it normally functions, when HER2 is overexpressed, cell growth accelerates beyond its normal limits, which happens in some cancers, notably certain types of breast cancer.

Purification: Protein A or G affinity column

Pureté: >95 % by reducing SDS-PAGE

niveau d'endotoxine: < 1 EU per 1 mg of the protein by the LAL method

Immunogène: A431 cells overexpressing human EGFR

Isotype: L234A, L235A, P329G

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: > 3 mg/mL

Stock: 4 °C,-20 °C

Stockage commentaire: Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.

Détails sur ErbB2/Her2 (Trastuzumab Biosimilar)

Antigène: ErbB2/Her2 (Trastuzumab Biosimilar)

Autre désignation: Trastuzumab Biosimilar

Classe de substances: Biosimilar