Cet anticorps Souris Monoclonal détecte spécifiquement MS4A1 (Rituximab Biosimilar) dans FACS et in vivo. Il présente une réactivité envers Humain.
N° du produit ABIN7795085
Aperçu rapide pour Recombinant MS4A1 (Rituximab Biosimilar) anticorps (ABIN7795085)
Antigène
MS4A1 (Rituximab Biosimilar)
Type d'anticorp
Recombinant Antibody
Reactivité
Humain
Hôte
Souris
Clonalité
Monoclonal
Conjugué
Cet anticorp MS4A1 (Rituximab Biosimilar) est non-conjugé
Application
Flow Cytometry (FACS), In vivo Studies (in vivo)
Classe de qualité
Research Grade
Expression System
Mammalian cells
Fonction
Rituximab Biosimilar, Endotoxin 0.05 EU/mg
Attributs du produit
B-lymphocyte antigen CD20 encoded by the MS4A1 gene is an activated-glycosylated phosphoprotein on the surface of all B-cells. The function of the membrane protein is to stimulate B-cell immune response, specifically against T-independent antigens though its natural ligand remains unknown. CD20 is important for the development and differentiation of B-cells into plasma cells. CD20 belongs to the membrane-spanning 4A family with common structural features, similar intron/exon splice boundaries, and unique expression patterns among hematopoietic cells and nonlymphoid tissues. Rituximab, a chimeric anti-CD20 monoclonal antibody, destroys B cells and is used to treat diseases with excessive numbers of B cells, overactive B cells, or dysfunctional B cells, such as many lymphomas, leukemias, transplant rejection, and autoimmune disorders.
Purification
Protein A or G affinity column
Pureté
>95 % by reducing SDS-PAGE
niveau d'endotoxine
Less than 0.5 EU/mg of protein as determined by LAL method