Recombinant CD3E (Muromonab Biosimilar) anticorps
Aperçu rapide pour Recombinant CD3E (Muromonab Biosimilar) anticorps (ABIN7795115)
Antigène
Type d'anticorp
Reactivité
Hôte
Clonalité
Conjugué
Application
Classe de qualité
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Expression System
- Mammalian cells
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Fonction
- Muromonab Biosimilar, CD3 Monoclonal Antibody
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Attributs du produit
- Muromonab Biosimilar uses the same protein sequences as the therapeutic antibody muromonab (OKT3). Muromonab (OKT-3) is a monoclonal anti-CD3 antibody used as immunosuppressive therapy in kidney, heart, and liver transplant patients. Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93 % monomeric immune globulin G type 2a (IgG2a). Muromonab binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.
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Purification
- Protein A or G affinity column
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Pureté
- >95 % by reducing SDS-PAGE
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niveau d'endotoxine
- < 1 EU per 1 mg of the protein by the LAL method
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Immunogène
- Human CD3
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- > 3 mg/mL
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Stock
- 4 °C,-20 °C
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Stockage commentaire
- Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.
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- CD3E (Muromonab Biosimilar)
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Autre désignation
- Muromonab Biosimilar
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Classe de substances
- Biosimilar
Antigène
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