Recombinant Trop2 (Sacituzumab Biosimilar) anticorps

N° du produit ABIN7795133

Cet anticorps Humanized Monoclonal détecte spécifiquement Trop2 (Sacituzumab Biosimilar) dans FACS et in vivo. Il présente une réactivité envers Humain.

Aperçu rapide pour Recombinant Trop2 (Sacituzumab Biosimilar) anticorps (ABIN7795133)

Antigène: Trop2 (Sacituzumab Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Humanized

Clonalité: Monoclonal

Conjugué: Cet anticorp Trop2 (Sacituzumab Biosimilar) est non-conjugé

Application: Flow Cytometry (FACS), In vivo Studies (in vivo)

Classe de qualité: Research Grade

Détail du produit anti-Trop2 (Sacituzumab Biosimilar) anticorps

Expression System: Mammalian cells

Fonction: Sacituzumab Biosimilar, Endotoxin 0.05 EU/mg

Attributs du produit: What is sacituzumab biosimilar research grade? Sacituzumab Biosimilar uses the same protein sequences as the therapeutic antibody sacituzumab. Sacituzumab govitecan is a Trop-2-directed antibody and topoisomerase inhibitor drug conjugate used for the treatment of metastatic triple-negative breast cancer and metastatic urothelial cancer. Triple-negative breast cancer is a type of breast cancer that tests negative for estrogen receptors, progesterone receptors and human epidermal growth factor receptor 2 (HER2) protein. Therefore, triple-negative breast cancer does not respond to hormonal therapy medicines or medicines that target HER2. Sacituzumab govitecan is a conjugate of the humanized anti-Trop-2 monoclonal antibody linked with SN-38, the active metabolite of irinotecan. Each antibody having on average 7.6 Molecules of SN-38 attached. SN-38 is too toxic to administer directly to patients, but linkage to an antibody allows the drug to specifically target cells containing Trop-2.

Purification: Protein A or G affinity column

Pureté: >95 % by reducing SDS-PAGE

niveau d'endotoxine: Less than 0.5 EU/mg of protein as determined by LAL method

Immunogène: Human Trop-2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: > 3 mg/mL

Stock: 4 °C,-20 °C

Stockage commentaire: Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.

Détails sur Trop2 (Sacituzumab Biosimilar)

Antigène: Trop2 (Sacituzumab Biosimilar)

Autre désignation: Sacituzumab Biosimilar

Classe de substances: Biosimilar