Cet anticorps Lapin Monoclonal détecte spécifiquement Neurofibromin 1 dans WB, IP et FACS. Il présente une réactivité avec des échantillons de Humain et Souris.
IP,20 μL/mg lysate,WB,11000,Flow-Cyt,Fixed in 4 % formaldehyde and permeabilized with 90 % methanol. 1 μL per 1 x 10^6 cells.
Restrictions
For Research Use only
Format
Liquid
Concentration
100 μg/mL
Buffer
Phosphate Buffered Saline (PBS) with 0.1 % BSA and 0.09 % Sodium Azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
2 - 8 °C
Date de péremption
12 months
Antigène
Neurofibromin 1 (NF1)
Autre désignation
Neurofibromin 1
Sujet
Inactivating mutations in NF1 (neurofibromin 1) result in neurofibromatosis type I (NF1) which is characterized by Schwann cell neurofibromas, café-au-lait spots, and benign lesions of the iris. At the cellular level, NF1 functions as a negative regulator of Ras activity. Loss of NF1 leads to increased levels of active Ras-GTP which is important for the formation and maintenance of Schwann cell tumors.