SOD1 anticorps

N° du produit ABIN737346

Cet anticorps anti-SOD1 est un anticorps Lapin Polyclonal détectant SOD1 dans WB, IHC (p) et IF (p). Adapté pour Humain, Souris, Rat et Boeuf (Vache). Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour SOD1 anticorps (ABIN737346)

Antigène: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOD1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-SOD1 anticorps

Réactivité croisée: Boeuf (Vache), Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from mouse SOD1

Isotype: IgG

Information d'application

Indications d'application: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Références pour anticorps anti-SOD1 (ABIN737346)

Li, He, Zhang, Miao: "Differential proteome and gene expression reveal response to carbon ion irradiation in pubertal mice testes." dans: Toxicology letters, Vol. 225, Issue 3, pp. 433-44, (2014) (PubMed).

Détails sur SOD1

Antigène: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Autre désignation: SOD1

Sujet:

Synonyms: Superoxide Dismutase 1, ALS 1, ALS, ALS1, Amyotrophic lateral sclerosis 1 adult, Amyotrophic lateral sclerosis 1, Cu/Zn SOD, Cu/Zn superoxide dismutase, Homodimer, Indophenoloxidase A, IPOA, Mn superoxide dismutase, SOD 1, SOD, SOD soluble, SOD1, SOD2, SODC, Soluble indophenoloxidase A, Superoxide dismutase 1, Superoxide dismutase 1 soluble, Superoxide dismutase Cu Zn, Superoxide dismutase cystolic, SODC_HUMAN, Superoxide dismutase [Cu-Zn], hSod1, Ipo1, SODC, Ipo-1, Sod-1, CuZnSOD, Cu/Zn-SOD, MGC107553, B430204E11Rik, superoxide-dimutase-1.

Background: SOD1 encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. Mutations in the copper/ zinc superoxide dismutase (SOD1) gene are associated with 15- 20 % of the familial forms of motoneuron disease. This 153 amino acid metalloenzyme is expressed in virtually all cells of all organisms above bacteria and is highly conserved across species, although some minor variations do occur. The incorporation of the mutated form of the SOD1 human gene into a transgenic mouse leads to the onset of the disease that closely resembles the human condition. These animals become weak at about 2-4 months of age and rapidly lose function, which results in death 4- 6 weeks later.

Poids moléculaire: 17kDa

ID gène: 20655

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis