Runx1 + Runx2 (AA 202-300) anticorps

N° du produit ABIN738156

Détail du produit

Antigène: Runx1 + Runx2

Épitope: AA 202-300

Reactivité: Cobaye, Humain, Souris, Lapin, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Cobaye, Humain, Souris, Lapin, Rat

Homologie: Dog,Cow,Sheep,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human RUNX2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Référence

Sun, Kiraly, Cox, Mauerhan, Hanley: "The role of inhibition by phosphocitrate and its analogue in chondrocyte differentiation and subchondral bone advance in Hartley guinea pigs." dans: Experimental and therapeutic medicine, Vol. 15, Issue 4, pp. 3320-3328, (2018) (PubMed).

Li, Deng, Wei, Jayasuriya, Zhou, Chen, Zhang, Wei, Wei: "Blockade of hypoxia-induced CXCR4 with AMD3100 inhibits production of OA-associated catabolic mediators IL-1β and MMP-13." dans: Molecular medicine reports, Vol. 14, Issue 2, pp. 1475-82, (2016) (PubMed).

Hu, Wang, Zhou, Shang: "High expression of periostin is dramatically associated with metastatic potential and poor prognosis of patients with osteosarcoma." dans: World journal of surgical oncology, Vol. 12, pp. 287, (2014) (PubMed).

Zhang, Men, Fu, Shan, Ye, Wu, Tao, Liu, Jiang: "Contribution of SATB2 to the stronger osteogenic potential of bone marrow stromal cells from craniofacial bones." dans: Cell and tissue research, Vol. 350, Issue 3, pp. 425-37, (2013) (PubMed).

Gao, Zhao, Song, Yang: "Expression pattern of embryonic stem cell markers in DFAT cells and ADSCs." dans: Molecular biology reports, Vol. 39, Issue 5, pp. 5791-804, (2012) (PubMed).

Détail du antigène

Antigène: Runx1 + Runx2

Autre désignation: RUNX1+RUNX2

Sujet:

Synonyms: CCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1, Runt-related transcription factor 2, Acute myeloid leukemia 3 protein, Core-binding factor subunit alpha-1, Oncogene AML-3, Osteoblast-specific transcription factor 2, Polyomavirus enhancer-binding protein 2 alpha A subunit, PEA2-alpha A, PEBP2-alpha A, SL3-3 enhancer factor 1 alpha A subunit, SL3/AKV core-binding factor alpha A subunit, RUNX2, PEBP2A

Background: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.

ID gène: 860

UniProt: Q13950