Runx1 + Runx2 (AA 202-300) anticorps

N° du produit ABIN738156

Cité dans 6 publications. Cet anticorps anti-Runx1 + Runx2 Polyclonal Lapin (ABIN738156) détecte spécifiquement Runx1 + Runx2 dans WB, FACS, IF (cc), IF (p), ELISA, IHC (fro) et IHC (p). L’anticorps est réactif avec des échantillons de Cobaye, Humain, Souris, Lapin et Rat.

Aperçu rapide pour Runx1 + Runx2 (AA 202-300) anticorps (ABIN738156)

Antigène: Runx1 + Runx2

Reactivité: Cobaye, Humain, Souris, Lapin, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit

Épitope: AA 202-300

Réactivité croisée: Cobaye, Humain, Souris, Lapin, Rat

Homologie: Dog,Cow,Sheep,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human RUNX2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Référence

Sun, Kiraly, Cox, Mauerhan, Hanley: "The role of inhibition by phosphocitrate and its analogue in chondrocyte differentiation and subchondral bone advance in Hartley guinea pigs." dans: Experimental and therapeutic medicine, Vol. 15, Issue 4, pp. 3320-3328, (2018) (PubMed).

Li, Deng, Wei, Jayasuriya, Zhou, Chen, Zhang, Wei, Wei: "Blockade of hypoxia-induced CXCR4 with AMD3100 inhibits production of OA-associated catabolic mediators IL-1β and MMP-13." dans: Molecular medicine reports, Vol. 14, Issue 2, pp. 1475-82, (2016) (PubMed).

Hu, Wang, Zhou, Shang: "High expression of periostin is dramatically associated with metastatic potential and poor prognosis of patients with osteosarcoma." dans: World journal of surgical oncology, Vol. 12, pp. 287, (2014) (PubMed).

Zhang, Men, Fu, Shan, Ye, Wu, Tao, Liu, Jiang: "Contribution of SATB2 to the stronger osteogenic potential of bone marrow stromal cells from craniofacial bones." dans: Cell and tissue research, Vol. 350, Issue 3, pp. 425-37, (2013) (PubMed).

Gao, Zhao, Song, Yang: "Expression pattern of embryonic stem cell markers in DFAT cells and ADSCs." dans: Molecular biology reports, Vol. 39, Issue 5, pp. 5791-804, (2012) (PubMed).

Détail du antigène

Antigène: Runx1 + Runx2

Autre désignation: RUNX1+RUNX2

Sujet:

Synonyms: CCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1, Runt-related transcription factor 2, Acute myeloid leukemia 3 protein, Core-binding factor subunit alpha-1, Oncogene AML-3, Osteoblast-specific transcription factor 2, Polyomavirus enhancer-binding protein 2 alpha A subunit, PEA2-alpha A, PEBP2-alpha A, SL3-3 enhancer factor 1 alpha A subunit, SL3/AKV core-binding factor alpha A subunit, RUNX2, PEBP2A

Background: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.

ID gène: 860

UniProt: Q13950