Anti-PABPN1 Antibody catalog # A02445-2. Tested in WB, IHC, IF, ICC, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
Purification
Immunogen affinity purified.
Immunogène
A synthetic peptide corresponding to a sequence in the middle region of human PABPN1. Human PABPN1 shares 100% amino acid (aa) sequence identity with mouse PABPN1.
PABPN1
Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Lapin, Porc
WB, IP
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat Immunohistochemistry, 2-5 μg/mL, Human, Mouse, Rat Immunofluorescence, 5 μg/mL, Human Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human Immunoprecipitation, 0.5-2 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
Antigène
PABPN1
(Poly A Binding Protein Nuclear 1 (PABPN1))
Autre désignation
PABPN1
Sujet
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.