Recombinant HMGCR anticorps

N° du produit ABIN7827985

Cet anticorps Lapin Monoclonal détecte spécifiquement HMGCR dans WB, IP, FACS et IF. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour Recombinant HMGCR anticorps (ABIN7827985)

Antigène: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp HMGCR est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: A254

Détail du produit anti-HMGCR anticorps

Fonction: Recombinant HMGCR Monoclonal Antibody

Purification: Protein A purified

Immunogène: Recombinant human HMG-CoA Reductase fragment

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:500-1:2000,IF 1:50,FCM 1:50-1:100,IP 1:25

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur HMGCR

Antigène: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Autre désignation: HMGCR

Sujet: LDLCQ,HMGCR,LDLCQ3,3-hydroxy-3-methylglutaryl-CoA reductase,3-hydroxy-3-methylglutaryl-CoA reductase,LDLCQ3,3-hydroxy-3-methylglutaryl-coenzyme A reductase,HMG-CoA reductase,3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is a transmembrane glycoprotein of the endoplasmic reticulum. It is the rate-limiting enzyme for cholesterol biosynthesis and non-sterol isoprenoid biosynthesis. Play a key role in cellular cholesterol homeostasis. The activity of HMGCR is regulated by negative feedback, in which cholesterol and other end products of the metabolic pathway inhibit the activity of HMGCR in a multivalent manner. Cholesterol inhibits reductase activity mainly by inhibiting the transcription rate of HMGCR gene. HMGCR is the main target of statins, which are a class of cholesterol-lowering drugs. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 97 kDa

Observed MW: 97 kDa

UniProt: P04035

Pathways: AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha