Recombinant ASCL1 anticorps

N° du produit ABIN7827989

L’anticorps anti-ASCL1 Monoclonal Lapin est utilisé pour la détection de ASCL1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Recombinant ASCL1 anticorps (ABIN7827989)

Antigène: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp ASCL1 est non-conjugé

Application: Western Blotting (WB)

Clone: A718

Détail du produit anti-ASCL1 anticorps

Fonction: Recombinant MASH1 Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:1000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur ASCL1

Antigène: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Autre désignation: MASH1

Sujet: ASH,ASCL,HASH,MASH,bHLHa,ASCL1,ASH1,HASH1,MASH1,bHLHa46,Achaete scute complex homolog 1,Achaete scute complex homolog like 1,Achaete scute complex homologue 1,Achaete scute complex homologue like 1,Achaete scute complex like 1,Achaete scute family bHLH transcription factor 1,Achaete scute protein,Achaete-scute homolog 1,Ascl 1,Ash 1,ASH-1,Class A basic helix-loop-helix protein 46,Hash 1,Mammalian achaete scute homolog 1,Mammalian achaete scute homologue 1,Mash 1,MASH1, also known as achaete-scute homolog 1 (ASCL1), is a basic helix-loop-helix (BHLH) transcription factor which plays an essential role in the differentiation of neuroendocrine cells and neural tissues. MASH1 directly binds the E-box motif (5'-CANNTG-3') on promoters, with dimerization with other BHLH proteins required for efficient DNA binding. Acting as a pioneer transcription factor, MASH1 also accesses closed chromatin, allowing other factors to promote transcription of neuronal genes and activate neural pathways. Research studies have shown that knockdown of the MASH1 gene leads to inhibition of growth and induction of apoptosis in SCLC cells in vitro. Additionally, MASH1 is overexpressed in both classic SCLC as well as NSCLC with neuroendocrine features, suggesting its role in the pathogenesis of those malignancies. MASH1 plays a crucial role in promoting SCLC carcinogenesis by upregulating the expression of DLL3, a nonfunctioning Notch ligand, leading to inhibition of the Notch signaling pathway. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 25 kDa

Observed MW: 30 kDa The actual band is not consistent with the expectation.

UniProt: P50553

Pathways: Dopaminergic Neurogenesis