Recombinant ANGPTL3 anticorps

N° du produit ABIN7828020

Cet anticorps anti-ANGPTL3 Monoclonal Lapin (Clone A133) (ABIN7828020) détecte spécifiquement ANGPTL3 dans WB, IHC et IF. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour Recombinant ANGPTL3 anticorps (ABIN7828020)

Antigène: ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp ANGPTL3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: A133

Détail du produit anti-ANGPTL3 anticorps

Fonction: Recombinant ANGPTL3 Monoclonal Antibody

Purification: Protein A purified

Immunogène: Synthetic peptide derived from ANGPTL3 anti

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:500-1:1000,IHC 1:50-1:100,IF 1:50

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur ANGPTL3

Antigène: ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))

Autre désignation: ANGPTL3

Sujet: ANG,UNQ,PRO,FHBL,Angiopoietin,angiopoietin like,Angiopoietin-like protein,Angiopoietin-related protein,ANGPT,ANGPTL,ANGPTL3,ANG-5,ANGPT5,ANL3,FHBL2,angiopoietin like 3,Angiopoietin-5,Angiopoietin-like protein 3,Angiopoietin-related protein 3,ANL,UNQ153,PRO179,ANG-5,ANGPT5,ANL3,FHBL2,Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface, the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1. Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids. Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol. Suppresses LPL specifically in oxidative tissues which is required to route very low density lipoprotein (VLDL)-TG to white adipose tissue (WAT) for storage in response to food, the function may involve cooperation with circulating, liver-derived ANGPTL8 and ANGPTL4 expression in WAT. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 54 kDa

Observed MW: 54 kDa

UniProt: Q9Y5C1