Recombinant CPS1 anticorps

N° du produit ABIN7828062

Cet anticorps anti-CPS1 Monoclonal Lapin (Clone A622) (ABIN7828062) détecte spécifiquement CPS1 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Recombinant CPS1 anticorps (ABIN7828062)

Antigène: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CPS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A622

Détail du produit anti-CPS1 anticorps

Fonction: Recombinant CPS1 Monoclonal Antibody

Purification: Protein A purified

Immunogène: Recombinant human CPS1 fragment

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:1000-1:5000,IHC 1:50-1:100

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur CPS1

Antigène: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Autre désignation: CPS1

Sujet: CPS,carbamoyl-phosphate synthase,CPSASE,CPS1,CPSASE1,PHN,carbamoyl-phosphate synthase 1,carbamoyl-phosphate synthase 1,CPSASE1,PHN,Carbamoyl phosphate synthase,Carbamoyl phosphate synthase [ammonia],Carbamoyl phosphate synthase [ammonia] mitochondrial,Carbamoyl phosphate synthetase 1,Carbamoyl phosphate synthetase 1 mitochondrial,Carbamoyl phosphate synthetase I,Carbamoylphosphate synthase,Carbamoyl-phosphate synthase [ammonia],Carbamoylphosphate synthetase 1,Carbamoylphosphate synthetase I,Carbamoyl-phosphate synthetase I,CPS 1,CPSase 1,CPSase I,CPSM,mitochondrial,MS738,Carbamoyl phosphate synthetase 1 (CPS1), a rate-limiting enzyme in the urea cycle, catalyzes the conversion of ammonia and bicarbonate to carbamoyl phosphate in mitochondria. Non-small cell lung carcinoma (NSCLC) cells with oncogenicKRASand loss of the tumor suppressor LKB1 express CPS1 and depend on this enzyme for growth. CPS1 maintains pyrimidine/purine balance in these cancer cells. Silencing CPS1 reduces the pyrimidine to purine ratio and stalls DNA synthesis, leading to DNA damage and cancer cell death. In addition, the tumor suppressor p53 represses the expression of urea cycle enzymes CPS1, OTC, and ARG1 and, therefore, causes the accumulation of ammonia, suppressing cancer growth. Furthermore, research studies suggest that hypermethylation-mediated downregulation ofCPS1expression may contribute to the progression of normal hepatocytes to hepatocellular carcinoma (HCC). Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 165 kDa

Observed MW: 165 kDa

UniProt: P31327

Pathways: Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process