Recombinant GABBR1 anticorps

N° du produit ABIN7828218

Cet anticorps anti-GABBR1 Monoclonal Lapin (Clone A650) (ABIN7828218) détecte spécifiquement GABBR1 dans WB et IHC. L’anticorps est réactif avec des échantillons de Rat et Souris.

Aperçu rapide pour Recombinant GABBR1 anticorps (ABIN7828218)

Antigène: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Type d'anticorp: Recombinant Antibody

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp GABBR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A650

Détail du produit anti-GABBR1 anticorps

Fonction: Recombinant GABA B Receptor 1 Monoclonal Antibody

Purification: Protein A purified

Immunogène: Recombinant human GABA B Receptor 1 fragment

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:1000,IHC 1:200-1000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur GABBR1

Antigène: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Autre désignation: GABA B Receptor 1

Sujet: GABBR,GABABR,GABBR1,GABABR1,GABBR1-3,GB1,GPRC3A,GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission. Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site. GABA(B)R1 has two isoforms: GABA(B)R1a and GABA(B)R1b. GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein. G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 108 kDa

Observed MW: 108 kDa

UniProt: Q9UBS5

Pathways: Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process