Recombinant HOXB13 anticorps

N° du produit ABIN7828292

L’anticorps anti-HOXB13 Monoclonal Lapin est utilisé pour la détection de HOXB13 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Recombinant HOXB13 anticorps (ABIN7828292)

Antigène: HOXB13 (Homeobox B13 (HOXB13))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp HOXB13 est non-conjugé

Application: Western Blotting (WB)

Clone: A632

Détail du produit anti-HOXB13 anticorps

Fonction: Recombinant HOXB13 Monoclonal Antibody

Purification: Protein A purified

Immunogène: Recombinant human HOXB13 fragment

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:1000-1:5000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur HOXB13

Antigène: HOXB13 (Homeobox B13 (HOXB13))

Autre désignation: HOXB13

Sujet: HXB,Homeobox B,Homeo box B,Homeobox protein HoxB,Homeobox protein Hox B,Homeobox protein Hox-B,HOX B,HOXB13,PSGD,Homeo box B13,Homeobox B13,Homeobox protein Hox B13,Homeobox protein HoxB13,Homeobox protein Hox-B13,HOX B13,HOXB 13,HXB13,PSGD protein,HOXB13 is a member of the HOXB cluster which, along with the HOXA, HOXC, and HOXD clusters, governs embryonic patterning along the cranio-caudal axis. HOXB13 plays a key role in the development of the ventral prostate, where it is expressed highly from the embryonic stage through adulthood. Research studies have shown that both overexpression and RNA interference can inhibit the growth of prostate cancer cells. HOXB13 can function as a tumor suppressor by negatively regulating growth through repression of TCF4 and androgen receptor (AR) signaling. However, HOXB13 has also been shown to be overexpressed in more invasive prostate cancers, breast and ovarian cancers, and hepatocellular carcinomas. A common germline mutation G84E in the HOXB13 protein has recently been found to be associated with significant increased risk of prostate cancer. Currently, HOXB13 is being evaluated as a marker for metastatic lesions of prostate origin. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 31 kDa

Observed MW: 31 kDa

UniProt: Q92826