Recombinant HOMER1 anticorps

N° du produit ABIN7828294

Cet anticorps Lapin Monoclonal détecte spécifiquement HOMER1 dans WB et IHC. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant HOMER1 anticorps (ABIN7828294)

Antigène: HOMER1 (Homer Homolog 1 (HOMER1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp HOMER1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A255

Détail du produit anti-HOMER1 anticorps

Fonction: Recombinant Homer1 Monoclonal Antibody

Purification: Protein A purified

Immunogène: Recombinant human Homer1 fragment

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:500-1:1000,IHC 1:200-1:1000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur HOMER1

Antigène: HOMER1 (Homer Homolog 1 (HOMER1))

Autre désignation: Homer1

Sujet: Vesl,HOMER,Vesl1,Homer1,Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 5 counteracts the effects by competing for binding sites. Isoform 3 regulates the trafficking and surface expression of GRM5. Isoform 5 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, isoform 2 and isoform 3 to regulate synaptic metabotropic glutamate function. Isoform 5, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 41 kDa

Observed MW: 46 kDa The actual band is not consistent with the expectation.

UniProt: Q9Z2Y3

Pathways: Skeletal Muscle Fiber Development