Recombinant SET7 anticorps

N° du produit ABIN7828560

Cet anticorps anti-SET7 Monoclonal Lapin (Clone A733) (ABIN7828560) détecte spécifiquement SET7 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant SET7 anticorps (ABIN7828560)

Antigène: SET7 (SETD8P1) (SET Domain Containing 8 Pseudogene 1 (SETD8P1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp SET7 est non-conjugé

Application: Western Blotting (WB)

Clone: A733

Détail du produit anti-SET7 anticorps

Fonction: Recombinant SET7 Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:1000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur SET7

Antigène: SET7 (SETD8P1) (SET Domain Containing 8 Pseudogene 1 (SETD8P1))

Autre désignation: SET7

Sujet: KMT,SETD,KIAA,SET,SETD7,KMT7,SET7,SET7/9,SET9,KIAA1717,SET7/SET9 is a member of the SET domain-containing family, and can specifically methylate Lys4 on histone H3. Like most other lysine directed histone methyltransferases, it contains a conserved catalytic SET domain originally identified in the Drosophila Su(var)3-9, Enhancer of zeste and Trithorax proteins. Histone methylation is a major determinant for the formation of active and inactive regions of the genome and is crucial for the proper programming of the genome during development. Methylation of histone H3 Lys4 enhances transcriptional activation by coordinating the recruitment of BPTF, a component of the NURF chromatin remodeling complex, and WDR5, a component of multiple histone methyltransferase complexes. In addition, methylation of lysine 4 blocks transcriptional repression by inhibiting the binding of the NURD histone deacetylation complex to the amino-terminal tail of histone H3 and interfering with SUV39H1 mediated methylation of histone H3 Lys9. SET7/SET9 is highly active on free histone H3, but only very weakly methylates H3 within nucleosomes. Besides histones, SET7/SET9 also methylates Lys189 of the TAF10, a member of the TFIID transcription factor complex, and Lys372 of the p53 tumor suppressor protein. Methylation of TAF10 stimulates transcription in a promoter-specific manner by increasing the affinity of TAF10 for RNA polymerase II, which may potentiate pre-initiation complex formation. Methylation of p53 at Lys372 increases protein stability and leads to upregulation of target genes such as p21. Thus the loss of SET7/SET9 may represent another mechanism for the inactivation of p53 in human cancers. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 41 kDa

Observed MW: 47 kDa The actual band is not consistent with the expectation.

UniProt: Q8WTS6