Recombinant STING/TMEM173 anticorps

N° du produit ABIN7828638

Cet anticorps anti-STING/TMEM173 Monoclonal Lapin (Clone A369) (ABIN7828638) détecte spécifiquement STING/TMEM173 dans WB, IHC et IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant STING/TMEM173 anticorps (ABIN7828638)

Antigène: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp STING/TMEM173 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: A369

Détail du produit anti-STING/TMEM173 anticorps

Fonction: Recombinant STING Monoclonal Antibody

Purification: Protein A purified

Immunogène: Recombinant human STING fragment

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:500-1:2000,IHC 1:200-1:1000,IF 1:50

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur STING/TMEM173

Antigène: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Autre désignation: STING

Sujet: NET,TMEM,TMEM173,ERIS,MITA,MPYS,NET23,SAVI,STING,hMITA,hSTING,Mediator of IRF3 activation,Stimulator of interferon genes protein,STING1,endoplasmic reticulum IFN stimulator,Endoplasmic reticulum interferon stimulator,FLJ38577,Mitochondrial mediator of IRF3 activation,N terminal methionine proline tyrosine serine plasma membrane tetraspanner,Stimulator of interferon genes,TM173,Transmembrane protein 173,STING has several transmembrane domains, and is expressed in a variety of endothelial cells, epithelial cells and hematopoietic liver cells. STING participates in the DNA-mediated innate immune response. Non-CpG double-stranded DNA from viruses or bacteria binds to cGAS protein and is catalyzed to the second messenger cGAMP, then the dimerized STING binds to cGAMP and undergoes conformational changes. Through the autophagsome and the endoplasmic reticulum and the Golgi apparatus, it further enters the cytoplasm. During the period, it is ubiquitinated and recruited TBK1 protein, then phosphorylated, and then combined with IRF3, then IRF3 is phosphorylated and enters the nucleus to induce the expression of IFNs, etc. In conclusion, it can enhance the body's immune ability and kill bacteria, viruses and other pathogens to a greater extent. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 42 kDa

Observed MW: 36 kDa The actual band is not consistent with the expectation.

UniProt: Q86WV6

Pathways: Activation of Innate immune Response