Recombinant TTR anticorps

N° du produit ABIN7828640

L’anticorps anti-TTR Monoclonal Lapin est utilisé pour la détection de TTR dans des échantillons de Humain. Il a été validé pour WB et IHC.

Aperçu rapide pour Recombinant TTR anticorps (ABIN7828640)

Antigène: TTR (Transthyretin (TTR))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TTR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A768

Détail du produit anti-TTR anticorps

Fonction: Recombinant Prealbumin/Transthyretin Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:1000,IHC 1:1000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur TTR

Antigène: TTR (Transthyretin (TTR))

Autre désignation: Prealbumin/Transthyretin

Sujet: HEL,HsT,TTR,CTS,CTS1,HEL111,HsT2651,PALB,TBPA,ATTR,Prealbumin,Transthyretin,Amyloid polyneuropathy,Amyloidosis I,Carpal tunnel syndrome 1,Dysprealbuminemic euthyroidal hyperthyroxinemia,Dystransthyretinemic hyperthyroxinemia,Epididymis luminal protein 111,Prealbumin amyloidosis type I,Prealbumin Thyroxine-binding,Senile systemic amyloidosis,Thyroxine binding prealbumin,Transthyretin,TTR,TTHY,TTR protein,Transthyretin (TTR) is a highly conserved homotetremric protein that is synthesized in the liver and choroid plexus of the brain. TTR wasoriginally discovered as a protein found in human plasma and cerebrospinal fluid (CSF). TTR transports thyroid hormones (TH) and retinol bybinding to retinol-binding protein. Although TTR is synthesized in the liver and choroid plexus, TTR is detected in blood plasma andcerebrospinal fluid migrating as monomers, dimers, and tetramers. Beyond its function as a carrier protein of TH and retinol in plasma andCSF, several additional TTR functions have been described, including proteolytic cleavage of specific substrates like apolipoprotein,neuropeptide Y (NPY), and APP. These neuronal substrates suggest a functional role for TTR in the central nervous system. Consistent witha CNS function, TTR null mice exhibit memory impairments and altered sensorimotor behavior). TTR may also be linked to neurodegenerativedisease: TTR levels in Alzheimer's disease (AD) patients are negatively correlated with disease progression, and a protective role for TTR, atleast in AD mouse models, has been described. TTR itself may play a more direct role in disease as gain-of-function mutations in TTR causethe protein to misfold and aggregate into amyloid fibrils, contributing to autosomal dominant hereditary amyloidosis in diseases such as familialamyloid polyneuropathy, familial amyloid cardiomyopathy, and familial leptomeningeal amyloidosis. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 16 kDa

Observed MW: 35 kDa The actual band is not consistent with the expectation.

UniProt: P02766

Pathways: Hormone Transport