CD163 anticorps (AA 1001-1121) (FITC)

N° du produit ABIN741577

Cet anticorps Lapin Polyclonal détecte spécifiquement CD163 dans WB, FACS, IF (cc) et IF (p). Il présente une réactivité envers Humain, Souris, Rat, Porc et Chien et a été mentionné dans 3+ publications.

Aperçu rapide pour CD163 anticorps (AA 1001-1121) (FITC) (ABIN741577)

Antigène: CD163

Reactivité: Humain, Souris, Rat, Porc, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD163 est conjugé à/à la FITC

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-CD163 anticorps (FITC)

Épitope: AA 1001-1121

Réactivité croisée: Chien, Humain, Souris, Porc, Rat

Homologie: Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CD163/M130

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-CD163 (FITC) (ABIN741577)

Kobori, Hamasaki, Kitaura, Yamazaki, Nishinaka, Niwa, Nakao, Wake, Mori, Yoshino, Nishibori, Takahashi: "Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis." dans: Frontiers in immunology, Vol. 9, pp. 334, (2019) (PubMed).

Oh, Riek, Zhang, Williams, Darwech, Bernal-Mizrachi: "Deletion of JNK2 prevents vitamin-D-deficiency-induced hypertension and atherosclerosis in mice." dans: The Journal of steroid biochemistry and molecular biology, Vol. 177, pp. 179-186, (2017) (PubMed).

Weng, Sprague, Oh, Riek, Chin, Garcia, Bernal-Mizrachi: "Vitamin D deficiency induces high blood pressure and accelerates atherosclerosis in mice." dans: PLoS ONE, Vol. 8, Issue 1, pp. e54625, (2013) (PubMed).

Détails sur CD163

Antigène: CD163

Autre désignation: Cd163/M130

Sujet:

Synonyms: M13, MM13, Scavenger receptor cysteine-rich type 1 protein M13, Hemoglobin scavenger receptor, CD163, M130

Background: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

ID gène: 9332

UniProt: Q86VB7