SREBF2 anticorps (Biotin)

N° du produit ABIN741707

L’anticorps anti-SREBF2 Polyclonal Lapin est utilisé pour la détection de SREBF2 dans des échantillons de Humain. Il a été validé pour IHC (p) et IHC (fro).

Aperçu rapide pour SREBF2 anticorps (Biotin) (ABIN741707)

Antigène: SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SREBF2 est conjugé à/à la Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-SREBF2 anticorps (Biotin)

Fonction: SREBP2 Polyclonal Antibody, Biotin Conjugated

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SREBP-2

Isotype: IgG

Information d'application

Indications d'application: IHC-P(1:200-400), IHC-F(1:100-500)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur SREBF2

Antigène: SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))

Autre désignation: SREBP-2

Sujet:

Synonyms: Sterol Regulatory Element Binding Protein-2, MGC124823, Srebf2_retired, SREBP-2, SREBP2, SRBP2_HUMAN, Sterol regulatory element-binding protein 2, SREBP-2, Class D basic helix-loop-helix protein 2, bHLHd2, Sterol regulatory element-binding transcription factor 2, Processed sterol regulatory element-binding protein 2.

Background: Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active forms (50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol. ab30682 detects both precursor and active forms of SREBP2 in tissues and cells such as liver, brown fat, testis, HepG2 cells, and human fibroblast. The apparent molecular weight on SDS-PAGE may be higher than the calculated molecular weight (about 126 kDa) due to glycosylation of the protein.

Poids moléculaire: 126kDa

ID gène: 6721

Pathways: Regulation of Lipid Metabolism by PPARalpha