ASIC1 anticorps

N° du produit ABIN742425

Cet anticorps anti-ASIC1 Polyclonal Lapin (ABIN742425) détecte spécifiquement ASIC1 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ASIC1 anticorps (ABIN742425)

Antigène: ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASIC1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ASIC1 anticorps

Fonction: ACCN2 Polyclonal Antibody

Réactivité croisée: Humain, Souris, Rat

Homologie: Cow,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ASIC1

Isotype: IgG

Information d'application

Indications d'application: WB(1:300-5000)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur ASIC1

Antigène: ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))

Autre désignation: Asic1/Bnac2/Asic1a

Sujet:

Synonyms: Acid-sensing ion channel 1, ASICs1, Acid sensing ion channel 1, Acid sensing ion channel 1a protein, Acid sensing ion channel, AI843610, Amiloride sensitive cation channel 2 neuronal, ASIC, ASIC1, ASIC1A, B530003N02Rik, BNAC2, Brain sodium channel 2, Cation channel amiloride sensitive neuronal 2, hBNaC2.

Background: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.

ID gène: 41