ASIC1 anticorps (Biotin)

N° du produit ABIN742427

Détail du produit anti-ASIC1 anticorps (Biotin)

Antigène: ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASIC1 est conjugé à/à la Biotin

Application: Western Blotting (WB)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ASIC1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:100-1000, IHC-P: 1:100-500
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur ASIC1

Antigène: ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))

Autre désignation: Asic1/Bnac2/Asic1a (ACCN2 Produits)

Synonymes: anticorps ACCN2, anticorps ASIC, anticorps BNaC2, anticorps Accn2, anticorps ASIC1, anticorps AI843610, anticorps ASIC1a, anticorps B530003N02Rik, anticorps acid sensing ion channel subunit 1, anticorps acid-sensing (proton-gated) ion channel 1, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1, anticorps ASIC1, anticorps Asic1, anticorps asic1, anticorps SMARCD1

Sujet:

Synonyms: Acid-sensing ion channel 1, ASICs1, Acid sensing ion channel 1, Acid sensing ion channel 1a protein, Acid sensing ion channel, AI843610, Amiloride sensitive cation channel 2 neuronal, ASIC, ASIC1, ASIC1A, B530003N02Rik, BNAC2, Brain sodium channel 2, Cation channel amiloride sensitive neuronal 2, hBNaC2.

Background: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.

ID gène: 41