Recombinant FOLR1 anticorps (Extracellular Domain)

N° du produit ABIN7865461

L’anticorps anti-FOLR1 Monoclonal Lapin est utilisé pour la détection de FOLR1 dans des échantillons de Humain, Souris, Rat et Cobaye. Il a été validé pour WB et IHC.

Aperçu rapide pour Recombinant FOLR1 anticorps (Extracellular Domain) (ABIN7865461)

Antigène: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat, Cobaye

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp FOLR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: FOLR1-13424R

Détail du produit anti-FOLR1 anticorps

Épitope: AA 1-200, Extracellular Domain

Expression System: CHO Cells

Fonction: Recombinant Folate Receptor Alpha (FRalpha) / FOLR1 Antibody

Specificité: Folate receptor alpha (FR±) is a membrane-bound protein that facilitates high-affinity folate transport, essential for cell metabolism, DNA synthesis, and repair, particularly in rapidly dividing cancer cells with increased folate demands. This receptor, encoded by the FOLR1 gene, employs a potocytosis mechanism that leads to both membranous and cytoplasmic localization and is selectively overexpressed in certain epithelial malignancies while remaining highly restricted in normal tissues. FR± expression correlates with tumor stage and grade, suggesting a role in tumor progression by enhancing folate uptake or generating regulatory signals. Its regulation is influenced by extracellular folate levels, homocysteine accumulation, hormones, transcription factors, and genetic mutations. Members of the folate receptor family share highly conserved sequences in the open reading frames but differ in amino acids in the 5' untranslated regions and as a consequence can differ in function and tissue expression. Given the selective overexpression of FR± in tumors and its association with aggressive cancer phenotypes, FR± is a valuable marker for studying tumor biology and progression, particularly in epithelial cancers.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogène: Recombinant fragment (around aa1-200) of human FOLR1 protein corresponding to the extracellular domain (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur FOLR1

Antigène: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Autre désignation: Folate Receptor Alpha

Sujet:

DOM, PCWH, SOX10, SRY (sex determining region Y) box 10, SRY box containing gene 10, SRY related HMG box gene 10, Waardenburg syndrome type 2E(WS2E), WS4, Waardenburg syndrome type 4C (WS4C)

Human kidney, thymus, placenta or lung. Human Brain, Mouse Brain, Rat Brain or Guinea pig Brain

Poids moléculaire: 29kDa

ID gène: 2348

UniProt: P15328

Pathways: Dicarboxylic Acid Transport