Recombinant PVRL4 anticorps (Extracellular Domain)

N° du produit ABIN7865529

L’anticorps anti-PVRL4 Monoclonal Lapin est utilisé pour la détection de PVRL4 dans des échantillons de Humain. Il a été validé pour IHC et FACS.

Aperçu rapide pour Recombinant PVRL4 anticorps (Extracellular Domain) (ABIN7865529)

Antigène: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PVRL4 est non-conjugé

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: NECTIN4-13438R

Détail du produit anti-PVRL4 anticorps

Épitope: AA 266-280, Extracellular Domain

Expression System: CHO Cells

Fonction: Recombinant Nectin 4 / Nectin Cell Adhesion Molecule 4 / PVRL4 Antibody

Specificité: Homologous to the poliovirus receptor (PVR/CD155), the nectin immunoglobulin superfamily comprises four known isoforms (-1, -2, -3, and -4). The ectodomain of nectin family members comprises three Ig-like domains (V, C, C). Nectins localize at the adherens junctions (AJ) in epithelial and endothelial cells where they serve as adhesion molecules. Actin-based AJs play a role in mechanical adhesion, cellular morphogenesis and cellular differentiation. Nectin associates with the Actin cytoskeleton through its interaction with the Actin filament-binding protein afadin. Nectin 4 and afadin co-localize at cadherin-based adherens junctions in MDCKII epithelial cells. Nectin 4 and Nectin 3 share a common binding region in the V domain of Nectin 1 and thus compete for Nectin 1 binding. The Nectin 3/4 binding domain maps to the C-C'-C''-D b strands of the V domain of Nectin 1. Unlike other nectins, which are more widely expressed, Nectin 4 is mainly expressed in the placenta.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogène: Recombinant fragment (around aa266-280) of human NECTIN4 protein corresponding to the extracellular domain (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur PVRL4

Antigène: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Autre désignation: Nectin 4

Sujet:

Ig superfamily receptor LNIR family, Nectin 4, poliovirus receptor-related 4, Processed poliovirus receptor-related protein 4, PRR4, PVRL4

Human tonsil, placenta or breast. MCF-7 or T47D cells.

Poids moléculaire: 66kDa

ID gène: 81607, 492490

UniProt: Q96NY8

Pathways: Cell-Cell Junction Organization