Recombinant Tyrosinase-Related Protein 1 anticorps (C-Term)

N° du produit ABIN7865490

Cet anticorps anti-Tyrosinase-Related Protein 1 Monoclonal Souris (Clone rG3E6) (ABIN7865490) détecte spécifiquement Tyrosinase-Related Protein 1 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant Tyrosinase-Related Protein 1 anticorps (C-Term) (ABIN7865490)

Antigène: Tyrosinase-Related Protein 1 (TYRP1)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Tyrosinase-Related Protein 1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: RG3E6

Détail du produit anti-Tyrosinase-Related Protein 1 anticorps

Épitope: C-Term

Expression System: CHO Cells

Fonction: Recombinant Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Antibody

Specificité: Tyrosinase-related protein-1 (TRP-1) is a member of a family of proteins which are involved in melanin biosynthesis. The catalytic function of TRP-1 has not been fully resolved but the enzyme appears to be important in the oxidation of 5,6-dihydroxyindole-2-carboxylic acid to form a high molecular weight pigmented biopolymer. In mammals, there are two basic types of melanin, the brown-black eumelanin and the reddish-yellow phaeomelanin. The concentrations of each are variable and are not related to skin type. In skin exposed to suberythemal doses of UVB, an increase in the number of melanocytes expressing TRP-1 and TRP-2 was observed with no increase noted in the number of tyrosinase-expressing melanocytes. In normal, untreated skin the number of melanocytes which immunohistochemically stain for either TRP-1, TRP-2 or tyrosinase appears to be similar irrespective of skin type. TRP-1 is also expressed in more than 50 per cent of choroidal melanocytes of the adult eye.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogène: Prokaryotic recombinant fusion protein corresponding to the C-terminus of the TRP-1 molecule

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Tyrosinase-Related Protein 1

Antigène: Tyrosinase-Related Protein 1 (TYRP1)

Autre désignation: Tyrosinase-Related Protein-1

Sujet:

5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75

SK-MEL-19, SK-MEL-23, SK-MEL-30 or SK-MEL-37 cells. Human Skin or Melanoma.

Poids moléculaire: 75kDa

ID gène: 7306, 270279

UniProt: P17643