Recombinant BST2 anticorps

N° du produit ABIN7865496

L’anticorps anti-BST2 Monoclonal Lapin est utilisé pour la détection de BST2 dans des échantillons de Humain. Il a été validé pour WB, ELISA, FACS et Func.

Aperçu rapide pour Recombinant BST2 anticorps (ABIN7865496)

Antigène: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp BST2 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Functional Studies (Func)

Clone: BST2-13681R

Détail du produit anti-BST2 anticorps

Expression System: CHO Cells

Fonction: Recombinant BST2 / Tetherin / CD317 (Target for Tumor Immunotherapy) Antibody

Specificité: Bone marrow stromal cells act as regulators for B-cell growth and development through their surface molecules and cytokines. Bone marrow stromal antigen-2 (BST-2), also designated CD317 antigen, is a single-pass type II membrane protein. BST-2, which is expressed mainly on synovial cell lines and bone marrow stromal cell lines, is primarily expressed in liver, heart, placenta and lung tissues. BST-2 is thought to be involved in pre-B cell growth. It has been implicated in B cell activation in rheumatoid arthritis. IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogène: Recombinant BST2 protein

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur BST2

Antigène: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Autre désignation: BST2

Sujet:

Bone Marrow Stromal Cell Antigen 2, NPC-A-7, PDCA-1

Human adrenal gland or ovary. Spleen, HeLa, Raji, HEK293T or SiHa cells.

Poids moléculaire: 30-36kDa

ID gène: 684

UniProt: Q10589

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response