Recombinant CD39 anticorps

N° du produit ABIN7857782

Cet anticorps Souris Monoclonal détecte spécifiquement CD39 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant CD39 anticorps (ABIN7857782)

Antigène: CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD39 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: R22A9

Détail du produit anti-CD39 anticorps

Expression System: CHO Cells

Fonction: Recombinant CD39 / ENTPD1 (Marker of Tumor-specific T cells) Antibody

Specificité: CD39 is a transmembrane glycoprotein and an extracellular nucleotide-hydrolyzing enzyme that plays a key role in regulating extracellular ATP and ADP levels. Also known as E-type apyrase, CD39 hydrolyzes ATP and ADP to AMP, which is further converted to adenosine. By degrading ADP, CD39 inhibits platelet aggregation, contributing to its anti-thrombotic function and potential use in preventing coronary artery occlusion and thrombotic stroke. Intracellularly, CD39 undergoes glycosylation at six N-glycosylation sites before translocating to the membrane to become an active enzyme. Alternative splicing gives rise to three isoforms: vascular, placenta I, and placenta II, with variations at the N-terminus and C-terminus. CD39 is expressed in vascular tissues, including the placenta, lung, skeletal muscle, and kidney, as well as on endothelial cells, smooth muscle cells, cardiac cells, and platelets. In the immune system, CD39 is present on activated B cells, a subset of activated T cells, activated NK cells, macrophages, dendritic cells, and Langerhans cells. It is not expressed on resting lymphocytes but is found in lymphoid tissues, particularly in the mantle zone and paracortical lymphocytes. CD39-expressing cells may provide protection to lymphocytes from the toxic effects of ATP released from damaged cells. Originally identified on Epstein-Barr virus-transformed B cells, CD39 is now recognized as a key immunoregulatory enzyme involved in inflammation, immune suppression, and thrombotic balance.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogène: Prokaryotic recombinant protein corresponding to a portion of the external domain of the CD39 molecule

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur CD39

Antigène: CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))

Autre désignation: CD39

Sujet:

ATPDase, DKFZp686D194, DKFZp686I093, Ecto apyrase, Ecto ATP diphosphohydrolase, Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, FLJ40921, FLJ40959, Lymphoid cell activation antigen, NTPDase 1, SPG64

Human tonsil, placenta, kidney or lymph node.

Poids moléculaire: 70-100 kDa

ID gène: 953, 576612

UniProt: P49961